Natalie Portman has replaced Jennifer Lopez in Don Roos' upcoming drama Love And Other Impossible Pursuits, the first film from the $100m Incentive Filmed Entertainment fund launched by Screen Capital International and William Morris Agency at Cannes.

Jere Hausfater's Essential Entertainment will commence international pre-sales at AFM on the under-$15m film adapted from the novel by Ayelet Waldman about a woman who learns from her precocious step-son how to save her marriage. Roos, who previously directed the 2005 Sundance opening night film Happy Endings as well as The Opposite Of Sex, adapted the screenplay.

Production is set to begin in Manhattan on November 10 on the project, which also stars Scott Cohen and Charlie Tahan. William Morris is handling North American sales.

Marc Platt is producing and Portman will serve as executive producer through her production company Handsomecharlie Films, which has a first-look deal at Participant Productions.

Lopez pulled out after giving birth to twins earlier in the year.