Screen Gems and Constantin Film have started production in Toronto on Resident Evil: Afterlife, the first 3D instalment in the hit horror franchise.

Milla Jovovich returns as the zombie-fighting heroine Alice, while Ali Larter and Spencer Locke will also reprise their roles alongside newcomer and male lead Wentworth Miller, who plays a fighter pilot based on a popular character from the video game series.

Shawn Roberts will take over the role of Alice’s nemesis Wesker, and Boris Kodjoe and Kim Coates have also joined the cast.

Paul W S Anderson will write, direct and produce. Anderson wrote, produced and directed Resident Evil, which came out in 2002, and wrote and produced the sequels, Resident Evil: Apocalypse and Resident Evil: Extinction.

Producing alongside Anderson are Anderson’s business partner Jeremy Bolt, Constantin Film’s Bernd Eichinger and Robert Kulzer, as well as Samuel Hadida and Don Carmody. Martin Moszkowicz and Victor Hadida return as executive producers.

“Alice’s battle with The Umbrella Corporation isn’t finished,” Anderson said. “Last time we saw Alice, she let them know she was coming after them. It’s time to settle the score.”

Screen Gems’ President Clint Culpepper added: “The Resident Evil franchise has successfully entertained audiences around the globe and we are pleased to bring yet another installment to fans with the same creative team but this time in 3-D.”

The film is expected to open in autumn 2010. Screen Gems will handle the US, with Constantin Film distributing throughout German-speaking territories and Hadida’s Metropolitan Film Export releasing in France. Sony Pictures Releasing International will handle certain overseas markets.