Chan, whose last day will be Saturday (March 31), hasn't announced his next move and said he would be taking a short break in the interim. Media Asia's Fred Tsui will oversee his duties until a replacement is appointed.
'I had a good time and made a lot of friends - it was an interesting page in my life and my career,' Chan said of his five years with the company.
While at Media Asia, Chan oversaw international distribution of high-profile titles such as the Infernal Affairs trilogy, which was remade as The Departed, Andrew Lau and Alan Mak's Confession Of Pain and Johnnie To's Exiled.
Confession Of Pain is also heading for a remake via Warner Bros while Exiled is being remade by Samuel Hadida's Davis Films.