The comic book legend will collect the honour at the 23rd awards ceremony in Beverly Hills on Jan 21, 2012.
Lee is best known for his role at Marvel Comics, which in turn spawned Marvel Studios franchises based on such iconic characters as Spider-Man, The Incredible Hulk, X-Men and The Fantastic Four.
“Stan Lee’s creative vision and imagination has produced some of the most beloved and visually stunning characters and adventures in history,” PGA co-chairs Paula Wagner and Michael Manheim said. “Stan’s accomplishments truly encompass the spirit of the Vanguard Award and we are proud to honor him.”
Previous recipients include George Lucas and John Lasseter.