The comedy, based on Toby Young's book of the same name, stars Simon Pegg, Kirsten Dunst and Jeff Bridges.
MGM has struck a deal for North America and Paramount for the UK. Both will releases will kick off Oct 3.
London-based Intandem Films structured the finance for the film and handles sales duties.
Gary Smith, Intandem chairman, said: 'Our aim is to deliver studio level films with international appeal. How to Lose Friends has taken distributors by storm and with a third major studio on board to distribute, it demonstrates that our strategy is working.'
Stephen Woolley and Liz Karlsen produced for Number 9 Films, with financing from Aramid, Film 4 and the UK Film Council.
Intandem's previous sales to other territories include; Germany (Concorde/Telemunchen), Italy (Mikado), Portugal (Lusomundo), Turkey (Sanat Ozen), Korea (MFI), Poland (Hagi) and Benelux (RCV).








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