Apatow produced Forgetting Sarah Marshall, which opened in second place in the North American charts at the weekend, as well as 2007 hits like Superbad and Knocked Up, which he also wrote and directed along with 2005's The 40 Year Old Virgin.
Upcoming credits include producer roles on this summer's Pineapple Express and Step Brothers, and a writing credit on the Adam Sandler comedy You Don't Mess With The Zohan.
Meg Ryan will receive the first annual Compass Rose Acting Tribute Award.
The festival will run from June 19-22.
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