The awards will be handed out at the Hollywood Awards Gala Ceremony on Oct 22 at the Beverly Hilton Hotel.
'We are very proud that we will be recognising the great talent in Hairspray. The cast is a fantastic ensemble of multi-talented established and emerging actors,' Hollywood Film Festival founder and executive director Carlos de Abreu said.
New Line's musical has amassed more than $80m in North America since in opened three weeks ago and is one of the summer's most successful counter-programming releases.
Adam Shankman directed the adaptation of John Waters' cult film and the film stars John Travolta, Nikki Blonsky, Christopher Walken and Michelle Pfeiffer.
The 11th Annual Hollywood Film Festival will take place from Oct 17 to 22.