The DreamWorks Animation hit grossed an estimated $60m through Paramount, approximately 50% more than Sony's Adam Sandler comedy You Don't Mess With The Zohan, which launched in second place on $40m.
The two strong launches helped boost overall box office as the top 12 titles combined for $172.4m, approximately 32% ahead of the same weekend last year.
New Line/Warner Bros' Sex And The City tumbled 63% to fourth on $21.3m in its second weekend and stands at $99.3m. Indiana Jones And The Kingdom Of The Crystal Skull ranked third through Paramount on $22.8m for $253m.
Indy's stablemate Iron Man ranks sixth and should cross $300m by next weekend after $7.5m raised the tally to $288.9m.
Paramount Vantage's comedy The Foot First Way added $49,508 for $85,288 while Picturehouse launched Mongol on $133,136 from five screens.
Next weekend sees the arrival of Universal's The Incredible Hulk starring Edward Norton and Liv Tyler and Fox's R-rated M Night Shyamalan mystery The Happening with Mark Wahlberg.
Estimated Top 10 North America Jun 6-8, 2008
Film (Dist)/Int'l dist/Est wkd gross/Est total to date
1 (-) Kung Fu Panda (Paramount) PPI $60m -
2 (-) You Don't Mess With The Zohan (Sony) SPRI $40m -
3 (2) Indiana Jones And The Kingdom Of The Crystal Skull (Paramount)
PPI $22.8m $253m
4 (1) Sex And The City (New Line/Warner Bros) NLI $21.3m $99.3m
5 (3) The Strangers (Rogue) UPI $9.3m $37.6m
6 (4) Iron Man (Paramount) PPI/Various $7.5m $288.9m
7 (5) The Chronicles of Narnia: Prince Caspian (Buena Vista) WDSMPI
8 (6) What Happens In Vegas (Fox) Fox $3.4m $72.2m
9 (8) Baby Mama (Universal) UPI $779,000 $57.9m
10 (9) Made Of Honor (Sony) SPRI $775,000 $44.7m