Alan Moloney of Parallel Films and Stephen Woolley and Elizabeth Karlsen of Number 9 are producing the thriller set in contemporary Dublin.
Mark O'Rowe, who adapted Berlin title Boy A and Intermission, is writing the script for Ian Fitzgibbon to direct.
The fast-paced comedy-thriller is about three fugitives on the run from a gang boss.
The project was developed through Number 9's slate funding with Parallel, which is backed by Film4, Irish Film Board and the UK Film Council.
Nina Gold is handling casting for the film, set to shoot later this year.
McAvoy is represented by United Agents and William Morris, and his real-life wife Duff is represented by Gordon and French.