Festival organisers have culled 108 features and 92 shorts for the event, and the centerpiece screening will be Tom DiCillo's satirical comedy Delirious.
Organisers will also bestow two inaugural Midnight Awards honouring actors entering the prime of their careers to Rosario Dawson and Sam Rockwell. The first Chris Holter Humour in Film Award will go to the film-maker with the most heartening feature, documentary or short in the festival.
Events include international horror screenings in Spotlight: The Late Show that include Jonathan King's Black Sheep from New Zealand and David Bruckner, Dan Bush and Jacob Gentry's Sundance hit The Signal, as well as panel discussions and a technological focus in Spotlight: KinoTek.
As previously announced, Spike Lee will receive the Film Society Directing Award, Robins Williams will collect the Peter J Owens Award for acting, and Peter Morgan will collect the Kanbar Award for excellence in screenwriting.
The Film Society will honour George Lucas with the one-off Irving M Levin Award for his contribution to cinema. Historian and preservationist Kevin Brownlow will receive the Mel Novikoff Award, and documentarian Heddy Honigmann will collect the Golden Gate Persistence of Vision Award.
'A golden anniversary comes around only once in an organisation's lifetime,' San Francisco Film Society executive director Graham Leggat, said. 'And we intend to take full advantage of this remarkable occasion.'
For more details visit the official website at www.sffs.org.