The project, based on Jane Rogers' 1999 novel Island, will be co-directed by Elizabeth Mitchell (Argentina, Miscommunication) and Brek Taylor (The Man Who, The Kindness Of Strangers). Mitchell also wrote the screenplay.
The female film-making team also includes producer Charlotte Wontner of Hopscotch Films (The Sick House) and cinematographer Rain Li (Paranoid Park).
The film will start shooting in March with delivery for late summer.
The story follows a woman who swears revenge on the mother who abandoned her at birth.
High Point is introducing the project to buyers here at the EFM.
Burke also stars in Sundance selection and EFM title Donkey Punch (sold by Lumina) and Duff recently appeared in Garage and stars in another EFM project, French Film sold by The Works International.
'We were all utterly gripped by The Sea Change, a thoroughly compelling story with a really strong central female character at its centre and a devastating twist in the tail,' said High Point head Carey Fitzgerald. 'What's more it is so exciting and refreshing to see this film put together by an almost entirely female team of talent, including both directors. We are thrilled to be part of this unique project'
High Point's slate also includes Pieter Kuijpers' Rotterdam audience hit Nothing To Lose (TBS), and Lenny Abrahamson's four-part project Prosperity.