The screening at Apollo Cinemas Piccadilly Circus on October 31 will be the first time the film has played in the UK, coming a month before the territory premiere.
Meirelles is patron of ABC which supports street children in Brazil. His City Of God brought the issue to worldwide attention.
The director will take part in a Q&A after the event. Tickets are £25 per person are available on 0871 220 6000, or online www.apollocinemas.co.uk.