The arrangement gives Overture access to film product from Crescendo. Cheadle starred in the terrorism thriller Traitor that Overture released in August and went on to gross more than $23m.
This is the latest in a string of recently announced production deals that includes agreements with Philip Seymour Hoffman's Cooper's Town Productions, Peter Block's A Bigger Boat and Bob Teitel's and George Tillman's State Street Pictures.
Overture also recently struck a two-film deal with HS Media, the first of which will be an English-language remake of the Swedish vampire tale Let The Right One In.
Crescendo will maintain offices outside of Overture's Beverly Hills headquarters but will work closely with CEO Chris McGurk, COO Danny Rosett, worldwide marketing, distribution and new media president Peter Adee and the entire Overture team.
'There's no other company that we'd rather be in business with,' Cheadle said. 'All of us at Crescendo have a long and successful history with Chris and Danny that we are looking to build upon with this partnership.'
'Don Cheadle is really a unique presence in this business and we are fortunate to collaborate with a talent who commands such respect and admiration from the industry,' Rosett added. 'We know our lineup of projects can only become more interesting and appealing by partnering with creative minds like Don, Kay, and Lenore.'
Overture's upcoming releases are Nothing Like The Holidays on December 12 with John Leguizamo, Freddy Rodriguez, Alfred Molina and Debra Messing and Last Chance Harvey on December 25 starring Dustin Hoffman and Emma Thompson
In the pipeline are sci-fi thriller Pandorum starring Dennis Quaid and Ben Foster and Michael Moore's untitled documentary exploring the causes of the US financial collapse.