Pinewood Shepperton has seen its share price tumble after the Hollywood writers' strike forced the cancellation of a major US shoot.
The UK studio is facing a $6m (£3m) loss on the film.
Although the studio wasn't commenting, industry sources confirmed that the film concerned is Columbia Pictures'Angels & Demons, the prequel to the The Da Vinci Code. The project was already in preparation with a production office set up at Pinewood and plans to shoot in late February 2008.
It was announced last week that Ron Howard's movie would be delayed. Shepperton wasthe location for studio work after it had been used for the first movie.
Pinewood had already warned earlier this year that film revenue would be reduced because of strike-hit studio productions.
Ithad been performing well recently and was further boosted this year by news that it would host the next Bond movie. A Pinewood spokesman said there was no question at this stage of Bond being affected.
Recent business included Chris Weitz' His Dark Materials: The Golden Compass at Shepperton and Tim Burton's Sweeney Todd at Pinewood.
In September, Pinewood Shepperton announced half-year a39% year-on-year rise in pre-tax profits to $5.86m (£2.9m) on revenues of $36.8m (£18.3m), down a little from from $37.6 (£18.7m) in 2006. More than half of turnover comes from film with the rest from television.
The company has already announced that it intends to look to build its television business to increase stability.
'Pinewood Shepperton is making steady progress on our strategic developments for the future of the business as we move towards more diversified and higher quality revenue streams,' said Chief Executive Ivan Dunleavy.