Scotland is to host the shoot of John Maybury's $32m The Jacket, starring Adrien Brody and Keira Knightley.
The Jacket will be produced by George Clooney and Steven Soderbergh's Section Eight, with Peter Gruber's Mandalay Pictures in association with German fund VIP Medienfonds. Warner Bros has US rights and it is sold internationally by Summit Entertainment.
The film is the latest in a handful of big budget pictures to shoot in Scotland this year, including the $15m US indie biopic Bobby Jones - Stroke Of Genius starring Jim Caviezel, Harry Potter And The Prisoner Of Azkaban and the Jet Li, Morgan Freeman action thriller Danny The Dog.
Scottish Screen estimates that the The Jacket will generate around $10m for Scotland's economy and will employ a large film crew, the majority of whom will be recruited in Scotland.
The film goes into pre-production in late October and will shoot for seven weeks in Scotland during mid-January/February and March 2004. Some scenes will also be shot in Canada.
The Jacket is about a first Gulf War veteran who is unjustly accused of a murder he doesn't remember committing. Sent to an asylum for the criminally insane, he is put under the care of a Dr Becker who uses a torture device known as 'The Jacket'.
Negotiations are underway for scenes from the film to be shot at an old psychiatric hospital near Broxburn in West Lothian. A number of other locations are currently being identified around Scotland.
Frank McAveety, Scotland's Minister for Culture, commented: "Scottish Screen and the Glasgow Film Office must be congratulated in their roles in convincing the film's American and German producers that Scotland has everything to offer production companies who are looking for locations to shoot their films."