Playing in 9,870 screens, the James Bond action saga ranked number one everywhere and scored the 11th biggest international debut in history and the second biggest of the year behind Indiana Jones 4.
Quantum outperformed Casino Royale everywhere, led by $15.1m from 1,109 screens in Germany, $9.1m from 750 in Russia and $9.1m from 1,251 in China in the second biggest debut for a non-Chinese film.
Other highlights included $4.5m from 484 in South Korea, $4.3m from 490 in Italy and the biggest launch on record in director Marc Forster's native country of Switzerland on $3.8m from 172.
In its second weekend the film added $15.1m from 1,178 in the UK for a mighty $50.3m, $5.7m from 813 in France for $20.4m and $1.4m in Sweden from 149 for $5.3m.
In other launches, Quantum scored the second biggest launch for a non-Indian release in India on $3.5m from 570 and took $2.9m from 116 in Denmark, $2.3m from 93 in Norway, $2.2m from 135 in Holland, $2.1m from 128 in Austria, $2m from 403 in Brazil and $1.5m from 108 in Poland.
Quantum scored the biggest launch ever in Finland and the UAE on $1.7m from 64 and $1m from 37, respectively. Elsewhere it took $1.5m from 97 in Belgium, 125 in Greece, 114 in Malaysia and 149 in Thailand.
Taiwan generated $1.4m from 138, Singapore $1.3m from 70, Indonesia $1.2m from 75, Hong Kong $1.2m from 66, the Ukraine $1.1m from 94 and the Philippines $1m from 100.
There are four major territories to go including Australia, Spain, Mexico and Japan and the film opens next weekend in Mexico, Hungary and Vietnam.
High School Musical 3: Senior Year soared past $100m this weekend after adding $13.8m from 4,048 screens in 32 territories through Walt Disney Studios Motion Pictures International for $109.4m.
This becomes the division's fifth film to cross $100m. Key drivers were Italy on $2.6m for $11.9m, the UK on $2.2m for $31.9m, Germany on $1.6m for $13m, France on $1.3m for $11.9m, Spain on $1.1m for $9.5m and Mexico on $1m for $3.3m. The film opens in Russia next weekend.
Wall-E currently ranks as the eighth biggest overseas release of the year after adding $1.6m for $262m. It opens in Japan on December 5.
DreamWorks Animation's Madagascar: Escape 2 Africa followed up last weekend's sensational Russian launch with a $9.2m international haul from 770 sites in four territories to raise the tally to a highly promising $40.2m.
The film added $7.3m from Russia following a 55% drop for $35.8m and scored the second biggest launch for an animated release in Hungary behind Shrek The Third on $656,000 from 40 sites. The Philippines delivered a very solid $632,000 from 90.
Eagle Eye added $1.7m from 1,678 locations in 54 territories for $70.2m, Tropic Thunder raised its tally by $1.3m from 951 in 55 to $73.2m and Ghost Town added $1.1m from 335 in the UK for $7.2m.
Warner Bros Pictures International's terrorism thriller Body Of Lies added $5.2m from approximately 1,200 screens in 13 markets for $16.4m, powered by a $2.1m number one launch in Spain on 302 screens. The film launched in second place in France on $2.4m from 428.
The romance Nights In Rodanthe added $2.4m from more than 1,300 screens in 32 markets for $25.2m, powered by a number one launch in Australia that drew $960,000 from 240 screens. Spain has generated $3.1m after three weekends.
RocknRolla added $600,000 from 291 screens in three markets for $11.2m and raised its tally in the second weekend in Australia by $480,000 from 221 to $1.3m.
Mandate International's Saw V carved a further $5.1m out of the overseas market from approximately 2,000 screens in 30 territories for $23m.
The Coen Brothers' dark comedy Burn After Reading grossed $3.5m from 1,800 sites in 21 territories through UPI and Focus Features International buyers for $62m. There are 19 territories still to go including Hong Kong next weekend.
Universal's musical smash Mamma Mia! added $1.7m from 2,000 venues in 42 territories for $418m and raised its tally in Italy by $400,000 from 105 to $10.4m after six weekends. Japan will be the final major market to receive the film on January 30.
Death Race grossed an estimated $1.2m from 940 locations in 27 for $29.5m. The action remake launched at the top in New Zealand on $80,000 from 42 dates and held well in its second weekend in Mexico on $250,000 from 188 for $640,000. There are 20 territories to open over the next two months. Hellboy II: The Golden Army stands at $78.5m following a $1.1m weekend from 1,200 sites in 20 territories and has two territories to go including China on November 21 and Japan on January 9.
Fox International's The X-Files: I Want To Believe opened in Japan on $897,000 from 254 to push the international running total up to $45.2m. Max Payne added $2.2m from approximately 1,800 screens in 45 markets for $27.3m; the videogame adaptation blasts its ways into the UK, France and Switzerland next week.