The world premiere of DreamWorks Animation’s 3D summer tentpole Shrek Forever After will open the 2010 Tribeca Film Festival on April 21 in New York.

Mike Mitchell directed the familiar voice cast of Mike Myers, Eddie Murphy, Cameron Diaz and Antonio Banderas in what has been dubbed “the final chapter” in the adventures of the irascible green ogre.

In Shrek Forever After, a domesticated Shrek who yearns for the old days is duped into signing a contract with the smooth-talking Rumpelstiltskin, only to find himself in an alternate version of Far Far Away, where ogres are hunted, Rumpelstiltskin is king and Shrek and Fiona have never met. 

“We have always sought to open our festival with films that are captivating and strike an emotional chord with movie-goers,” festival co-founder Jane Rosenthal said. “Shrek Forever After combines the very best in storytelling and artistry while showcasing the wonders of innovative 3D film-making.”

“The final chapter of Shrek’s personal journey brings all of our beloved characters full circle in a way that pays creative homage to each of the previous films and the stories they told, while taking Shrek and his family and friends on a fantastic, emotion-filled journey that is funny at every turn,” Mitchell said.

Tribeca 2010 will unveil its line-up on March 10 and 15. The festival is scheduled to run from April 21-May 2. Paramount will release Shrek Forever After on May 21.