The Will Yun Lee thriller will receive its North American premiere on Oct 19.
The Hong Kong-made English-language feature stars Lee in a modern take on the traditional Wuxia tale about four killers who gather in a luxury hotel to resolve unfinished business.
Lee, who will soon be seen opposite Hugh Jackman as the Silver Samurai in The Wolverine, stars alongside Miguel Ferrer and Mercedes Renard.
Stanley J Orzel wrote and directed Four Assassins, which has won numerous awards on the festival circuit.
Hong Kong and Los Angeles-based Studio Strada produced in association with Hong Kong’s Distacom Communications Group.
Following the limited theatrical release the film will be released on DVD and VoD in November. US-based Multivisionnaire Pictures handles worldwide sales.