Buena Vista's juggernaut fell 62.4% to an estimated $43.2m as it raised its domestic tally to $216.5m. Including the $105.4m overseas haul, Pirates grossed $148.6m worldwide and stands at $625.3m. It already ranks as the 31st biggest release in history and the eighth Disney film to reach this amount.
Knocked Up, Judd Apatow's acclaimed follow-up to The 40 Year Old Virgin, opened in second on $29.3m and studio executives are hoping this could become one of the sleeper hits of the year. It should certainly stick around for the foreseeable future through strong word of mouth.
Paramount's Shrek The Third added $26.7m for $254.6m after three weekends, while the Kevin Costner serial killer drama Mr Brooks opened in fourth place for MGM on a little over $10m. Spider-Man 3 is showing definite signs of old age now, and added $7.5m in its fifth weekend for a $318.3m domestic tally.
Fox Searchlight's Sundance pick-up Waitress fell one place to sixth and stands at $9.5m after five, while Picturehouse's true-life drama Gracie opened in seventh on $1.4m. 28 Weeks Later ranks ninth and stands at $26.6m through Fox Searchlight after four.
Next weekend's wide releases are: Lionsgate's horror sequel Hostel 2 from director Eli Roth; Sony's animated family film Surf's Up; and Warner Bros' Ocean's Thirteen with George Clooney, Matt Damon, Brad Pitt and Al Pacino.
Estimated Top 10 North America June 1-3, 2007
Film (Distributor)/International distribution/Estimated weekend gross/Estimated total to date
1 (1) Pirates Of The Caribbean: At World's End (Buena Vista) BVI $43.2m $216.5m
2 (-) Knocked Up (Universal) UPI $29.3m -
3 (2) Shrek The Third (Paramount) PPI $26.7m $254.6m
4 (-) Mr Brooks (MGM) Element Films Int'l $10m -
5 (3) Spider-Man 3 (Sony) SPRI $7.5m $318.3m
6 (5) Waitress (Fox Searchlight) Fox Intl $2m $9.5m
7 (-) Gracie (Picturehouse) 2929 Int'l $1.4m -
8 (4) Bug (Lionsgate) Lionsgate $1.2m $6.1m
9 (6) 28 Weeks Later (Fox) Fox Intl $1.2m $26.6m
10 (7) Disturbia (Paramount) PPI $1.1m $76.7m