Alcon Entertainment has found its leading lady for the sci-fi project.
Cuban-born de Armas has starred in independent thriller Knock Knock and will be seen later this year in Hands Of Stone opposite Edgar Ramirez, and the comedy War Dogs with Miles Teller and Jonah Hill.
As previously announced, the Blade Runner sequel also stars Ryan Gosling, Harrison Ford, Robin Wright and Dave Bautista.
Denis Villeneuve directs and is scheduled to commence principal photography in July.
Warner Bros distributes in North America and Sony Pictures Releasing International around the rest of the world. The film opens worldwide on October 6, 2017.