IFC will release the film in 2009 through its theatrical and VOD day-and-date platform IFC in Theaters.
Medicine for Melancholy is a love story about a one-night stand told through the eyes of two African-American twentysomethings dealing with being a minority in a rapidly gentrifying San Francisco.
Barry Jenkins wrote the screenplay and made his feature directorial debut. Wyatt Cenac and Tracey Heggins star and Justin Barber and Cherie Saulter served as producers.
The film premiered in March at the SXSW and has won the San Francisco International Film Festival's audience award for best narrative feature and the Sarasota Film Festival's special jury award for cinematography.
IFC's vice president of acquisitions Arianna Bocco and manager of acquisitions Jeff Deutchman brokered the deal with George Rush on behalf of the film-makers.
Jenkins began his career as a director's assistant at Harpo Films and most recently wrote and directed the short films Little Brown Boy and My Josephine.
Strike Anywhere's second feature will be Amy Seimetz's City On A Hill, which is currently in post-production.