The release should dominate the charts despite anticipated strong competition from Sony Pictures Releasing International's (SPRI) Resident Evil: Extinction on 320 prints on the same day, Oct 12.
Ratatouille has amassed $250.4m and is expected to cross $300m by the end of its run. A strong UK run kicking off this weekend will go a long way toward reaching that goal.
WDSMPI also opens family drama The Game Plan - which has held on to the number one spot in North America for the last two weekends - in its first overseas market of Mexico on Oct 12.
Warner Bros Pictures International's revenge drama The Brave One has taken $14.6m from the early stages and executives will look to boost the tally with launches in Russia, South Korea and Australia on Oct 11 and Mexico on Oct 12.
Latest figures put Harry Potter And The Order Of The Phoenix on $644.7m, License To Wed on $26m, and No Reservations on $41.6m.
Apart from the UK, SPRI will open Resident Evil: Extinction in Australia on 125 prints on Oct 11, followed by Italy a day later on 250.
The zombie action romp has grossed $8.1m through six SPRI markets to date. The overall tally through all distributors was unavailable at time of writing. The comedy Superbad stands at $24.6m and Surf's Up has amassed $55.4m.
Universal/UPI's action drama The Kingdom gets a big push this weekend with 18 territories including Taiwan on Oct 10, Germany on Oct 11, Austria and Sweden on Oct 12, and Japan on Oct 13. The film has taken $4m from the early stages.
Meanwhile the comedy Knocked Up opens in France on Oct 10 and stands at $55.8m, while another comedy, Hot Fuzz, opens in Greece on Oct 11 and Mexico on Oct 12 and has amassed $54.8m.
Paramount/PPI's family fantasy Stardust goes out in 14 territories including French-speaking Switzerland on Oct 10, Argentina on Oct 11, and Brazil, Italy and South Africa on Oct 12. The film has amassed $26.9m to date.
The Heartbreak Kid opens in Spain on Oct 11 and stands at $6.6m, while the comedies Hot Rod and Year Of The Dog launch in Australia on Oct 11.
Fox International opens Seeker in six territories including Germany on Oct 11, Spain on Oct 12m and Taiwan on Oct 13.
28 Weeks Later stands at $33.9m, and Fantastic Four: Rise Of The Silver Surfer stands at $150.9m through Fox International.
Focus features' comedy Balls Of Fury opens in Russia on Oct 12.