Sheen, who recently appeared as a presenter at the Hollywood Film Awards, will next be seen in the drama Music Within and recently completed filming Ron Howard's adaptation Frost/Nixon for Universal. He also portrayed TV presenter David Frost in the acclaimed stage version of Peter Morgan's play.
'Michael's talent and ability to cross over between the big screen, stage, and television has established him as one of the best actors of his generation,' BAFTA/LA chairman Peter Norris said.
'He's also a fellow BAFTA/LA member, whom we know is always looking for new challenges. We are especially delighted that he has accepted our invitation to host what has now become a traditional and highly anticipated event in the entertainment community.'
Helen Mirren, Kathy Bates, Pierce Brosnan, Helen Fielding, Jodie Foster, Famke Janssen, Bill Nighy, and Reese Witherspoon will be among the presenters at this year's event.
As previously announced Denzel Washington will receive the Stanley Kubrick Britannia Award for Excellence in Film, Kate Winslet the Britannia Award for British Artist of the Year, and Martin Campbell the John Schlesinger Britannia Award for Artistic Excellence in Directing.
New Line's co-chairmen and co-chief executive officers Bob Shaye and Michael Lynne will receive the Cunard Britannia Award for Lifetime Contributions to International Film, and Richard Curtis will be in town to collect the inaugural BAFTA/LA Humanitarian Award.